Hi, my name is Bruno, I am from Switzerland, 64 years old, Pharmacist and since around 10 years independent entrepreneur in the Healthcare- and Life science Industry

When I was about 8 years old, I saw my grandmother pass away due to a sudden heart attack. She always was smiling, active, loving and seemed in good health. At the age of 14, my beloved grandfather was diagnosed from bone cancer and about 9 month later he died, suffering tremendously during his last few months. Later one of our friends, Samantha, was diagnosed with terminal breast cancer – she was only 28 years old.

These events left a deep mark within myself and I decided, I wanted to do something against it.

I worked for more than 25 years in the pharmaceutical industry, in many functions, leading a team of 280 people spread across 64 countries. I felt proud to be associated to a research-based company and proud of new treatments we were able to bring to the markets. But one thing always bothered me. New therapies seemed not to work in all patients, some were doing fantastic, other seemed not to respond to the treatment at all.

Why that?

And why didn’t we do anything to find out who will be a responder and who will not?

Evidence based Medicine:

The buzz word of that time was “evidence-based medicine”. This means, the medication will be tested, in what we call phase 3 clinical trials, in thousands of patients. At the end of the study we analysed the response rate and if, depending on the disease, at least 30 to 40 percent of the patients showed a positive response and the side effect profile was good, the product had high chances to be approved by Health Authorities and the medication could be introduced into the markets and prescribed to all patients, and not only a sub group. Evidence-based medicine means will allow to offer the treatment to all patients suffering from the same disease. Evidence based medicine applies to group of patients and populations. It looks at the average patient, not an individual.

So, does did mean I am “average”?

We are all individuals, and allow me to say,” my cancer is not like your cancer”. We might both be male, having both been diagnosed with the same cancer, say prostate cancer, but I am, although 99.9 percent genetically identical to any other human being, in 0.1 percent different to any other person, and this means, I show genetically more than 6 Mio differences to anyone else. I might be older, having a different medical history in general, different level of education, having been raised in a different part of the world and having been exposed to different toxic environments, and all of this is enough to reconsider the concept of “one size fits all “.

Wikipedia:Definition of EBM

Evidence-based medicine (EBM) is an approach to medical practice intended to optimize decision-making by emphasizing the use of evidence from well-designed and well-conducted research. Although all medicine based on science has some degree of empirical support, EBM goes further, classifying evidence by its logic strength and requiring that only the strongest types (coming from meta-analyses, systematic reviews, and randomized controlled trials) can yield strong recommendations; weaker types (such as from case-control studies) can yield only weak recommendations. The term was originally used to describe an approach to teaching the practice of medicine and improving decisions by individual physicians about individual patients. Use of the term rapidly expanded to include a previously described approach that emphasized the use of evidence in the design of guidelines and policies that apply to groups of patients and populations („evidence-based practice policies“). has subsequently spread to describe an approach to decision-making that is used at virtually every level of health care as well as other fields (evidence-based practice).

Whether applied to medical education, decisions about individuals, guidelines and policies applied to populations, or administration of health services in general, evidence-based medicine advocates that to the greatest extent possible, decisions and policies should be based on evidence, not just the beliefs of practitioners, experts, or administrators. It thus tries to assure that a clinician’s opinion, which may be limited by knowledge gaps or biases, is supplemented with all available knowledge from the scientific literature so that best practice can be determined and applied. It promotes the use of formal, explicit methods to analyse evidence and makes it available to decision makers. It promotes programs to teach the methods to medical students, practitioners, and policy makers.

From Wikipedia, the free encyclopaedia

https://en.wikipedia.org/wiki/Evidence-based_medicine

Leaving Big Pharma and getting independent

In 2007 I did, what I always wanted to do, but didn’t have the courage before, opening my first own company in health prevention and early detection In 2018 I started an initiative helping people finding clinics that offer more than average, one size fits all medicine, because …

I believe in “Precision Medicine “

Medicine that is taking care of you/me as an individual. Medicine that is suited to you/me. We are not average, nobody is.

Wikipedia: Definition of Precision medicine (PM)

Precision Medicine is a medical model that proposes the customization of healthcare, with medical decisions, treatments, practices, or products being tailored to the individual patient. In this model, diagnostic testing is often employed for selecting appropriate and optimal therapies based on the context of a patient’s genetic content or other molecular or cellular analysis. Tools employed in precision medicine can include molecular diagnostics, imaging, and analytics.

https://en.wikipedia.org/wiki/Precision_medicine

Precision Medicine refers to the tailoring of medical treatment to the individual characteristics of each patient. It does not literally mean the creation of drugs or medical devices that are unique to a patient, but rather the ability to classify individuals into subpopulations that differ in their susceptibility to a particular disease, in the biology or prognosis of those diseases they may develop, or in their response to a specific treatment. Preventive or therapeutic interventions can then be concentrated on those who will benefit, sparing expense and side effects for those who will not. Although the term ‚personalized medicine‘ is also used to convey this meaning, that term is sometimes misinterpreted as implying that unique treatments can be designed for each individual.

On the other hand, use of the term „precision medicine“ can extend beyond treatment selection to also cover creating unique medical products for particular individuals—for example, „…patient-specific tissue or organs to tailor treatments for different people.“ Hence, the term in practice has so much overlap with „personalized medicine“ that they are often used interchangeably.

The ability to provide precision medicine to patients in routine clinical settings depends on the availability of molecular profiling tests, e.g. individual germline DNA sequencing[. While precision medicine currently individualizes treatment mainly on the basis of genomic tests, several promising technology modalities are being developed, from techniques combining spectrometry and computational power to real-time imaging of drug effects in the body. Many different aspects of precision medicine are tested in research settings (e.g., proteome, microbiome), but in routine practice not all available inputs are used. The ability to practice precision medicine is also dependent on the knowledge bases available to assist clinicians in taking action based on test results. Early studies applying omics-based precision medicine to cohorts of individuals with undiagnosed disease has yielded a diagnosis rate ~35% with ~1 in 5 of newly diagnosed receiving recommendations regarding changes in therapy.

On the treatment side, PM can involve the use of customized medical products such drug cocktails produced by pharmacy compounding or customized devices. It can also prevent harmful drug interactions, increase overall efficiency when prescribing medications, and reduce costs associated with healthcare.

Artificial intelligence in Precision Medicine

Artificial intelligence is providing paradigm shift toward precision medicine. Machine learning algorithms are used for genomic sequence and to analyse and draw inferences from the vast amounts of data patients and healthcare institutions recorded in every moment. AI techniques are used in precision cardiovascular medicine to understand genotypes and phenotypes in existing diseases, improve the quality of patient care, enable cost-effectiveness, and reduce readmission and mortality rates.

Rosset-Pharma& Health-Consulting

The objective of my company is to offer you access to NEW, effective, safe, scientifically proven personalized therapies. A special focus is on integrated cancer treatments. (www.iaso-cancer.com)

In addition, I want people to know that there are clinics offering already today innovative treatments for patients with spinal cord injury, stroke, Multiple Sclerosis.

There are treatments that classical school Medicine rarely talks about and offers to the patients. It is not my intention to start a political debate on why this is the case and why it seems that promising treatments seemed to be delayed by the decision makers, using always the same excuse of needing more data, not enough evidence available. I leave it up to you to reflect what might be the cause of not making some therapies publicly available. I want to change this, but I won’t be able to do this on my own. I also realize that, unfortunately, most therapies I will talk about in future posts will not be covered by health insurance companies -this is sad, and we will work hard to change this. The more we talk about those therapies, the more patients we can demonstrate that the treatments are successful, the faster we will be able to change this situation.

I will also present innovative options and highly specialised teams of experts, who on an individual basis, will help patients overcome addictions, mental problems, or people who are struggling with overweight and who are looking to rejuvenate and recover health . (www.iaso-health.com)

I will try to make people understand how they can benefit from understanding their genetic pre-dispositions, and how they can build on their strengths and defeat the weaknesses.

I have carefully selected a network of clinics, all offering outstanding treatment and care. I am not employed by any of the clinics I may propose. I am not a medical Doctor, I work with independent Doctors who are my advisors and who have the same passion to bring successful, alternative, proven treatments to the patients’

To be transparent, I earn from medical tourism services I am offering to clients.

Please join me in the journey to “better health”. Do not hesitate to send me suggestions, articles you want me to publish, constructive criticism, or anything you feel you want to share with me and through my Blog. Looking forward hearing from you.

BR, February 20th, 2019